|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Of these 5 loci, 2 were found to be significantly associated with BD susceptibility: rs17375018 (G vs. A, OR = 1.50, 95% CI: 1.34-1.68, <i>P</i> < .00001) and rs924080 (T vs. C, OR = 1.36, 95% CI: 1.29-1.43, <i>P</i> < .00001).
|
31814470 |
2019 |
|
rs17375018
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Of these 5 loci, 2 were found to be significantly associated with BD susceptibility: rs17375018 (G vs. A, OR = 1.50, 95% CI: 1.34-1.68, <i>P</i> < .00001) and rs924080 (T vs. C, OR = 1.36, 95% CI: 1.29-1.43, <i>P</i> < .00001).
|
31814470 |
2019 |
|
rs11209032
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Only a systematic review was conducted for rs12119179, rs11209032, and rs12141431, owing to the lack of sufficient data.<b>Conclusion</b>: This meta-analysis indicated that rs17375018 (G/A) and rs924080 (T/C) were associated with BD susceptibility.
|
31814470 |
2019 |
|
rs12141431
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Only a systematic review was conducted for rs12119179, rs11209032, and rs12141431, owing to the lack of sufficient data.<b>Conclusion</b>: This meta-analysis indicated that rs17375018 (G/A) and rs924080 (T/C) were associated with BD susceptibility.
|
31814470 |
2019 |
|
rs12119179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only a systematic review was conducted for rs12119179, rs11209032, and rs12141431, owing to the lack of sufficient data.<b>Conclusion</b>: This meta-analysis indicated that rs17375018 (G/A) and rs924080 (T/C) were associated with BD susceptibility.
|
31814470 |
2019 |
|
rs27044
|
|
|
0.020 |
GeneticVariation |
BEFREE |
It was recognized in association with rs2287987, rs30187, rs17482078, and rs27044 BS-related polymorphisms for 4 out of 5 patients.
|
31790864 |
2020 |
|
rs4073153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed a significant decrease of the frequency of a <i>CARD9</i> gene haplotype CGCCA (rs4077515, rs11145769, rs59902911, rs9411205, rs4073153) in BD when compared to healthy controls (<i>Pc </i>= 0.012, OR = 0.585, 95%CI = 0.409 ~ 0.837).
|
31671006 |
2019 |
|
rs10515746
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two single-nucleotide polymorphisms of TIM-3 (rs9313439 and rs10515746) were genotyped in 212 patients with Behçet disease and 200 healthy controls.
|
31644615 |
2019 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
|
31602349 |
2019 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
|
31602349 |
2019 |
|
rs7528684
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the alleles revealed a significantly lower frequency of the A allele at the -169 site (rs7528684) in BD patients compared with that in controls (<i>P</i>=0.000, 66.4% versus 82%, χ<sup>2</sup>= 30.23).
|
31341856 |
2019 |
|
rs10454134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A higher frequency of both the rs10454134 AG genotypes (p = 0.008, OR = 1.413, 95% CI = 1.094-1.826) and a lower GG genotype frequency (p = 0.003, OR = 0.630, 95% CI = 0.465-0.854) were found in BD patients compared to the controls in the first stage.
|
31223615 |
2019 |
|
rs17482078
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Although preliminary, our data show a stronger association of rs17482078 with BS compa</span>red to rs27044 by means of case-control genetic analysis and bioinformatics prediction of protein structure change.
|
30820838 |
2019 |
|
rs27044
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Comparing patients and controls, we found a significant higher frequency of rs17482078 A allele (32.73% BS vs 17.69% HC, p = 0.007) and AA genotype (18.18% BS vs 0% HC; p = 0.0003) and rs27044 G allele (63.64% BS vs 46.92% HC; p = 0.0096) in BS group after Bonferroni correction.
|
30820838 |
2019 |
|
rs2066844
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that the association of MEFV with BD could be modulated by the HLA molecules; whereas the protective effect of NOD2 p.Arg702Trp would be independent of HLA.
|
30808881 |
2019 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045).
|
30730049 |
2019 |
|
rs30187
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, rs30187 showed the strongest association with BD in the recessive genotype model of the risk T allele in HLA-B*51 carriers.
|
30514861 |
2018 |
|
rs1342326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with BD exhibited a significantly higher prevalence of the T/G genotype of rs1342326</span> polymorphism compared with the control group.
|
30447310 |
2019 |
|
rs4936742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the UBASH3B gene rs4936742 (T > C) polymorphism is associated with an increased risk of Behcet's disease, especially non-ocular BD, in Iranian population.
|
30289285 |
2019 |
|
rs2910164
|
|
|
0.030 |
GeneticVariation |
BEFREE |
There was a significant association between microRNA-146a expression and eye activity (P = 0.033) and vascular activity (P = 0.041). miRNA-146a rs2910164 genotyping revealed that the frequency of CC genotype was higher in controls (12 vs 8.5%) and the frequency of GG genotype of rs2910164 was higher in the BD patients (59.6 vs 24%) (P = 0.138).
|
29987428 |
2019 |
|
rs10094579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
|
29907633 |
2018 |
|
rs224127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
|
29907633 |
2018 |
|
rs913678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD i</span>n an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
|
29907633 |
2018 |
|
rs9316059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
|
29907633 |
2018 |
|
rs428888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings demonstrate that FCGR3A/rs428888 confers genetic susceptibility for ocular BD in Han Chinese.
|
29555961 |
2018 |